Pain control is always essential. Unrelieved pain causes unnecessary suffering and further weakens someone with cancer. Whenever possible, pain is best relieved by treating the cancer. Pain may decrease when a tumour is removed by surgery or shrunk by radiation or chemotherapy. However, other pain relief treatments are generally needed. Most doctors will ask people to use painkillers on a regular basis and not on an "as needed" basis. This avoids causing people anxiety from delaying the start of pain relief and ensures consistent pain relief with fewer fluctuations in pain control.
When the pain is mild to moderate, pain relievers like acetaminophen* may work well. Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen are effective on bone pain.
If pain is severe, an opioid analgesic (strong painkillers from the medication family that includes morphine and codeine) may be prescribed. People will often continue to use acetaminophen in addition to opioid analgesics. Longer-acting opioids are often prescribed because they provide more hours of relief and are taken on a regular basis. Faster-acting opioid analgesics are taken on an as-needed basis and are used for pain that may break through the relief provided by longer-acting opioids.
Whenever possible, opioids are taken by mouth. However, some people are prescribed skin patches that deliver opioid analgesics through the skin. Others are given as injections or through a continuous infusion pump that's connected to a catheter placed in a vein or under the skin. Some infusion pump systems allow the patient to control the release of the medication by pressing a button.
Opioid analgesics do have some side effects such as nausea, itchiness, drowsiness, and constipation. If these side effects are bothersome, they can be managed – sometimes with other medications. Nausea and drowsiness will usually decrease as treatment continues. However, most people require medications to help with constipation.
Over time, some people need bigger doses of opioids to control pain because the pain has gotten worse or they've developed tolerance to the medication. However, there is no maximum dose of opioid medications for treating cancer pain. If tolerance develops, the opioid dose can be increased. Cancer pain is often inadequately treated. Some reasons for this include reluctance of the patient to bring up the pain (perhaps for fear of "bothering" their doctor or that their condition is worsening), reluctance of the doctor to inquire about pain or prescribe opioids, and fear of addiction.
When opioids are used to treat cancer pain, people do not get addicted. Addiction is defined as compulsive use in a person who craves the drug and uses it despite known potential consequences. People do become physically dependent and may experience withdrawal symptoms if the opioid is suddenly stopped, but they will not crave the medication. If the cancer is cured, most people stop using the opioid without serious difficulty. If the cancer can't be cured, being free of pain is essential.
Other mediations may also be helpful, especially for neuropathic (nerve) pain. These may include antidepressants, anticonvulsants, and muscle relaxants. Nerve blocks, where a local anesthetic is injected onto or near nerves, may also be used. For severe cases of pain related to cancers of the bone, medications called bisphosphonates may also be prescribed.
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